SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): Focal therapy is suitable for men with localized, low- to intermediate-risk prostate cancer (ISUP Grade 13). It preserves bladder, erectile, and bowel function, providing an effective, minimally invasive alternative to surgery or radiotherapy while maintaining quality of life. 00:00 Introduction: What Is Focal Therapy? 00:10 Tumor Criteria for Focal Therapy 00:41 Patient Considerations for Focal Therapy 01:05 When Surgery or Radiotherapy May Be Preferable 01:17 Balancing Cancer Control & Quality of Life Marc Laniado - https://www.thefocaltherapyclinic.co.uk/about-us/our-consultants/mr-marc-laniado/ Medical suitability - https://www.thefocaltherapyclinic.co.uk/focal-therapy/medical-suitability/

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SUMMARY

Mr. Alan Doherty (Consultant Urologist, The Focal Therapy Clinic): NanoKnife is ideal for prostate cancers located at the front of the gland, where HIFU may not deliver enough energy. It is particularly effective in targeted focal therapy for these cases, offering a precise and minimally invasive treatment option. Alan Doherty - https://www.thefocaltherapyclinic.co.uk/about-us/our-consultants/mr-alan-doherty/ https://www.thefocaltherapyclinic.co.uk/focal-therapy/nanoknife-ire-treatment/ Medical suitability - https://www.thefocaltherapyclinic.co.uk/focal-therapy/medical-suitability/

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SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): MRI fusion improves focal therapy accuracy, ensuring over 90% of men are cancer-free at one year. Globally, 7580% of men avoid radical treatment for 610 years post-focal therapy, making it an effective and minimally invasive option for prostate cancer. Marc Laniado - https://www.thefocaltherapyclinic.co.uk/about-us/our-consultants/mr-marc-laniado/ MRI US Fusion Technology - https://www.thefocaltherapyclinic.co.uk/focal-therapy/medical-suitability/mri-scans-prostate-cancer/ Success Rates - https://www.thefocaltherapyclinic.co.uk/focal-therapy/success-and-clinical-evidence/ 00:00 Introduction: MRI Fusion in Focal Therapy 00:04 Why MRI Fusion Matters (Precision & Accuracy) 00:14 One-Year Success Rates (Over 90% Cancer-Free) 00:22 Long-Term Success of Focal Therapy (Global Data) 00:34 Avoiding Radical Treatments (610 Years Control) 00:52 Key Takeaway: Precise, Minimally Invasive & Effective

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SUMMARY

Mr. Tim Dudderidge (Consultant Urologist, The Focal Therapy Clinic): Focal therapy is not typically used for metastatic prostate cancer, except in clinical trials like the ATLANTIS study. However, in some locally advanced cases, it may be an option for men who cannot or do not want surgery or radiotherapy, offering a targeted approach to treatment. Tim Dudderidge - https://www.thefocaltherapyclinic.co.uk/about-us/our-consultants/mr-tim-dudderidge/ Suitability - https://www.thefocaltherapyclinic.co.uk/focal-therapy/medical-suitability/ 00:00 Introduction: Focal Therapy & Metastatic Prostate Cancer 00:07 Clinical Trials: ATLANTIS Study & Experimental Role 00:19 Focal Therapy for Locally Advanced Disease 00:26 Patient Considerations (When Surgery/Radiotherapy Not Suitable) 00:56 Lower Success Rates in Advanced Disease 00:59 Multidisciplinary Team (MDT) Approach to Decision-Making

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SUMMARY

Mr. Alan Doherty (Consultant Urologist, The Focal Therapy Clinic): Age alone doesnt determine if focal therapy is appropriateit depends on cancer aggressiveness, overall health, and life expectancy rather than just a number. Personalized treatment decisions ensure the best outcomes for each patient. Mr Alan Doherty - https://www.thefocaltherapyclinic.co.uk/about-us/our-consultants/mr-alan-doherty/ Medical suitability - https://www.thefocaltherapyclinic.co.uk/focal-therapy/medical-suitability/ prostate cancer age discrimination - https://www.thefocaltherapyclinic.co.uk/blog/active-at-75-but-too-old-for-prostate-cancer-treatment-why-doctors-say-no/ 00:00 Introduction: Am I Too Old for Focal Therapy? 00:06 First Consideration: Do You Need Treatment at All? 00:12 The Goal of Treatment: Preventing Progression and Symptoms 00:25 When Treatment May Not Be Needed 00:27 Example: Early-Stage Cancer in a 90-Year-Old with Heart Disease 00:31 Why Some Cancers Shouldnt Have Been Found or Treated 00:35 When Treatment Makes Sense 00:37 Relevance for Younger, Healthier Men 00:41 Key Factors Beyond Age: Cancer Aggressiveness, Health, Longevity 00:49 Final Message: Focus on Cancer Necessity and Patient Fitness, Not Age

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SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): Gleason scores (67) and ISUP grade groups (13) indicate suitability for focal therapy. Higher grades (45) usually require surgery or radiotherapy, though some overlap exists depending on individual cases and treatment goals.

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SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): Focal therapy is best for localized, intermediate-risk cancers (ISUP 23). Widespread or high-grade cancers usually require whole-gland treatment or other therapeutic options. Selecting the right treatment depends on cancer staging and patient priorities.

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SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): The type of focal therapy depends on tumor location. HIFU is used for tumors at the back of the prostate, while NanoKnife or cryotherapy are preferred for tumors at the front. Outcomes and side effects are similar across techniques, and the choice depends on patient suitability and tumor characteristics.

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SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): The type of focal therapy depends on tumor location. HIFU is used for tumors at the back of the prostate, while NanoKnife or cryotherapy are preferred for tumors at the front. Outcomes and side effects are similar across techniques, and the choice depends on patient suitability and tumor characteristics.

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SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): We assess MRI and pathology reports to determine if cancer is confined to the prostate. Most cases are suitable for focal therapy, but higher-risk cancers may require other treatments such as surgery or radiotherapy. A precise diagnosis ensures the best treatment approach for each patient.

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SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): The Cambridge Prognostic Group (CPG) system helps guide prostate cancer treatment decisions. Men in groups 2 or 3 are often good candidates for focal therapy, while those in groups 4 or 5 may require surgery or radiotherapy for more aggressive disease.

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SUMMARY

Mr. Marc Laniado (Consultant Urologist, The Focal Therapy Clinic): Focal therapy for prostate cancer at the front has even fewer side effects. It avoids nerves affecting erections and reduces rectal risks, making it an excellent minimally invasive treatment option that preserves quality of life while effectively treating cancer.

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